Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population
Copyright policy )Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population
Background:Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings. Objective:This case-control study aimed to determine whether patients with NMO or with MS in an Afro-Caribbean population originating from French West Indies shared the same or different HLA class I and II pattern distribution. Methods:The association with HLA class II (DRB1 and DQB1) alleles was tested in 42 NMO patients, 163 MS patients and 150 healthy controls. HLA-DRB1 and DQB1 typing was undertaken on genomic DNA extracted from peripheral blood leucocytes. Results:By comparison with healthy controls, significantly increased frequency of HLA-DRB1*03 (26.2% vs. 13%, odds ratio 2.4, 95% confidence interval 1.31–4.28, p after correction, cp 0.045) was observed in patients with NMO. By contrast, in MS patients, HLA-DRB1*15 (24.8% vs. 13%, odds ratio 2.21, 95% CI 1.45–3.36, cp < 0.0015), but not DRB1*03 allele, was positively associated with the disease. Moreover, a modest protective effect of HLA-DRB1*11 in the MS group, independently of DRB1*15 association, was found (13.7% vs. 7% in controls, odds ratio 0.48, p 0.006), but did not survive Bonferroni correction. Conclusion:In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.
Adult, Male, Multiple Sclerosis, Neuromyelitis Optica, Black People, HLA-DR Antigens, Middle Aged, Risk Assessment, Phenotype, Gene Frequency, Case-Control Studies, HLA-DQ Antigens, Odds Ratio, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Martinique, Guadeloupe, HLA-DRB1 Chains
Adult, Male, Multiple Sclerosis, Neuromyelitis Optica, Black People, HLA-DR Antigens, Middle Aged, Risk Assessment, Phenotype, Gene Frequency, Case-Control Studies, HLA-DQ Antigens, Odds Ratio, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Martinique, Guadeloupe, HLA-DRB1 Chains
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