Widespread and sustained target engagement in Huntington’s disease minipigs upon intrastriatal microRNA-based gene therapy
Copyright policy ) Astrid Vallès; Melvin M. Evers; Anouk Stam; Marina Sogorb-Gonzalez; Cynthia Brouwers; Carlos Vendrell-Tornero; Seyda Acar-Broekmans; +16 Authors
Astrid Vallès; Melvin M. Evers; Anouk Stam; Marina Sogorb-Gonzalez; Cynthia Brouwers; Carlos Vendrell-Tornero; Seyda Acar-Broekmans; Lieke Paerels; Jiri Klima; Bozena Bohuslavova; Roberta Pintauro; Valentina Fodale; Alberto Bresciani; Roman Liscak; Dusan Urgosik; Zdenek Starek; Michal Crha; Bas Blits; Harald Petry; Zdenka Ellederova; Jan Motlik; Sander van Deventer; Pavlina Konstantinova;
Widespread and sustained target engagement in Huntington’s disease minipigs upon intrastriatal microRNA-based gene therapy
Striatal delivery of microRNA-gene therapy results in widespread brain huntingtin protein lowering in Huntington’s disease minipigs up to 1 year.
- St. Anne´s University Hospital Czech Republic
- IRBM Science Park Italy
- University of Veterinary and Pharmaceutical Sciences Czech Republic
- Na Homolce Hospital Czech Republic
Huntingtin Protein, Swine, Genetic Vectors, Genetic Therapy, Disease Models, Animal, MicroRNAs, Huntington Disease, Animals, Humans, Swine, Miniature, Tissue Distribution
Huntingtin Protein, Swine, Genetic Vectors, Genetic Therapy, Disease Models, Animal, MicroRNAs, Huntington Disease, Animals, Humans, Swine, Miniature, Tissue Distribution
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 45
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