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Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding

descriptionPublicationkeyboard_double_arrow_right Article 19 Dec 2013 English Publisher:American Society of HematologyJournal:Blood, volume 122, pages 4,165-4,171 (issn: 0006-4971, eissn: 1528-0020,

Authors: David L. Stokes; Barry S. Coller; Won-Seok Choi; William J. Rice;

doi: 10.1182/blood-2013-04-499194

pmid: 24136164

pmc: PMC3868924

Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding

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Abstract

Key PointsThe αIIbβ3 headpiece points away from the lipid bilayer, and the lower legs are either bent (αIIb) or freely coiled (β3). The linking region between the ecto- and TM domains likely transmits the TM conformational changes associated with inside-out activation.

Related Organizations

Rockefeller University
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University of Chicago
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New York University
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Osong Medical Innovation Foundation
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New York Structural Biology Center
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Keywords

Lipid Bilayers, Platelet Glycoprotein GPIIb-IIIa Complex, Crystallography, X-Ray, Ligands, Nanostructures, Protein Structure, Tertiary, Microscopy, Electron, Structure-Activity Relationship, Imaging, Three-Dimensional, Models, Chemical, Humans, Protein Binding

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33 Research products, page 1 of 4

Regulatory Role of the Extracellular α-Tail/β-Tail Interaction in αIIbβ3 Integrin Activation
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Identification of Interacting Hot Spots in the αIIb Extracellular Stalk By Computational Alanine Scanning
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Analysis of Integrin αIIb Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains
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Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus
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N-Glycosylation of the β-Propeller Domain of the Integrin α5 Subunit Is Essential for α5β1 Heterodimerization, Expression on the Cell Surface, and Its Biological Function
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Platelet glycoprotein IIIa
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Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	49
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
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Fields of Science (3) View all

medical and health sciences

basic medicine

Fields of Science

medical and health sciences

basic medicine

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