New insights into the spatiotemporal localization of prothrombinase in vivo

descriptionPublicationkeyboard_double_arrow_right Article 11 Sep 2014 English Publisher:American Society of HematologyJournal:Blood, volume 124, pages 1,705-1,714 (issn: 0006-4971, eissn: 1528-0020,

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Authors: Lacramioara, Ivanciu; Sriram, Krishnaswamy; Rodney M, Camire;

doi: 10.1182/blood-2014-03-565010

pmid: 24869936

pmc: PMC4162104

New insights into the spatiotemporal localization of prothrombinase in vivo

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Abstract

Key Points Prothrombinase bound in the vicinity of vascular damage is distributed away from platelets and is largely found on activated endothelium. The activated endothelium plays an unexpectedly important role in supporting prothrombinase assembly and function at the site of damage.

Related Organizations

University of Pennsylvania
United States
Children's Hospital of Philadelphia
United States

Keywords

Blood Platelets, Mice, Inbred BALB C, Thrombin, Thromboplastin, Arterioles, Mice, Platelet Adhesiveness, Factor Va, Factor Xa, Animals, Endothelium, Vascular

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