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Syntheses of colchicine and isocolchicine labelled with carbon‐11 or carbon‐13

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1995Publisher:WileyJournal:Journal of Labelled Compounds and Radiopharmaceuticals, volume 36, pages 521-528 (issn: 0362-4803, eissn: 1099-1344,

Authors: Paresh J. Kothari; Steven M. Larson; Ronald D. Finn;

doi: 10.1002/jlcr.2580360603

Syntheses of colchicine and isocolchicine labelled with carbon‐11 or carbon‐13

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Abstract

AbstractThe syntheses of isotopically labelled (−)‐10‐[11C/13C]‐colchicine and (−)‐9‐[11C/13C]‐ isocolchicine have been achieved from the reaction of (−)desmethylcolchicine with [11C/13C]‐iodomethane. The radiolabelled compounds, (−)‐10‐[11C]‐colchicine (11C‐n‐colchicine) and (−)‐9‐[11C]‐isocolchicine (11C‐i‐colchicine), were isolated by reversed phase HPLC. The total synthesis time was approximately 60 minutes for both radiolabelled compounds with an average specific activity of 240 mCi/μmol calculated to EOB. Utilizing a similar synthetic strategy, we also report the synthesis of milligram quantities of the carbon‐13 enriched compounds and the magnetic resonance signal assignment for (−)‐9‐[13C] isocolchicine.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

8 Research products, page 1 of 1

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	9
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average