Tumor Suppressors: Control of Signaling by Endocytosis
Copyright policy )Tumor Suppressors: Control of Signaling by Endocytosis
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.
- Heinrich Heine University Düsseldorf Germany
- University of Duesseldorf Germany
- University of Göttingen Germany
Agricultural and Biological Sciences(all), Endosomal Sorting Complexes Required for Transport, Receptors, Notch, Biochemistry, Genetics and Molecular Biology(all), Cell Polarity, Membrane Proteins, Epithelial Cells, Models, Biological, Endocytosis, Gene Expression Regulation, Animals, Drosophila Proteins, Drosophila, Carrier Proteins, Cell Proliferation, Signal Transduction
Agricultural and Biological Sciences(all), Endosomal Sorting Complexes Required for Transport, Receptors, Notch, Biochemistry, Genetics and Molecular Biology(all), Cell Polarity, Membrane Proteins, Epithelial Cells, Models, Biological, Endocytosis, Gene Expression Regulation, Animals, Drosophila Proteins, Drosophila, Carrier Proteins, Cell Proliferation, Signal Transduction
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