Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses
Copyright policy )Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses
Proton radiotherapy is becoming more common as protons induce more precise DNA damage at the tumor site with reduced side effects to adjacent normal tissues. However, the long-term biological effects of proton irradiation in cancer initiation compared with conventional photon irradiation are poorly characterized. In this study, using a human familial adenomatous polyposis syndrome susceptible mouse model, we show that whole-body irradiation with protons are more effective in inducing senescence-associated inflammatory responses (SIRs), which are involved in colon cancer initiation and progression. After proton irradiation, a subset of SIR genes (Troy, Sox17, Opg, Faim2, Lpo, Tlr2 and Ptges) and a gene known to be involved in invasiveness (Plat), along with the senescence-associated gene (P19Arf), are markedly increased. Following these changes, loss of Casein kinase Iα and induction of chronic DNA damage and TP53 mutations are increased compared with X-ray irradiation. Proton irradiation also increases the number of colonic polyps, carcinomas and invasive adenocarcinomas. Pretreatment with the non-steroidal anti-inflammatory drug, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid-ethyl amide (CDDO-EA), reduces proton irradiation-associated SIR and tumorigenesis. Thus exposure to proton irradiation elicits significant changes in colorectal cancer initiation and progression that can be mitigated using CDDO-EA.
Inflammation, Mice, Knockout, Aging, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Article, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, Adenomatous Polyposis Coli, Mutation, Disease Progression, Proton Therapy, Animals, Humans, Oleanolic Acid, Tumor Suppressor Protein p53, Colorectal Neoplasms, Whole-Body Irradiation, DNA Damage
Inflammation, Mice, Knockout, Aging, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Article, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, Adenomatous Polyposis Coli, Mutation, Disease Progression, Proton Therapy, Animals, Humans, Oleanolic Acid, Tumor Suppressor Protein p53, Colorectal Neoplasms, Whole-Body Irradiation, DNA Damage
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