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Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development

descriptionPublicationkeyboard_double_arrow_right Article 26 Nov 2021 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Immunology, volume 6 (eissn: 2470-9468,

Authors: Florian Ingelfinger; Marianne R. Spalinger; René Riedel; Ari Waisman; Florian Mair; Florian Mair; Ekaterina Friebel; +14 Authors

doi: 10.1126/sciimmunol.abf3111

pmid: 34797691

Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development

- Summary
- Subjects
- Related research
  (9)
- Metrics

Abstract

Thymic education of regulatory T cells is more important than negative selection in the prevention of autoimmunity.

Related Organizations

ETH Zurich
Switzerland
Helmholtz Association of German Research Centres
Germany
Hannover Medical School
Germany
Johannes Gutenberg University of Mainz
Germany
Institute of Molecular Health Sciences
Switzerland

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Keywords

Mice, Knockout, Autoimmunity, Epithelial Cells, Forkhead Transcription Factors, Thymus Gland, Protein Serine-Threonine Kinases, T-Lymphocytes, Regulatory, Mice, Inbred C57BL, Mice, Mice, Congenic, NF-kappaB-Inducing Kinase, Animals, Humans

9 Research products, page 1 of 1

NF kappa B-inducing kinase
2022IsRelatedTo
Mitogen-activated protein kinase kinase kinase 14
2017IsRelatedTo
Forkhead box N1
2017IsRelatedTo
Forkhead box N1
2017IsRelatedTo
Sequence Read Archive(SRA)
2022IsRelatedTo
Mitogen-activated protein kinase kinase kinase 14, isoform CRA_a
2017IsRelatedTo
Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development
2022IsRelatedTo
Map3k14 protein
2017IsRelatedTo
Forkhead box protein N1
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	8
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%