The aim: To determine the sources and terms of origin, developmental peculiarities and dynamics of ossification of the mandible during the prenatal period of human ontogenesis. Materials and methods: The research was carried out on the specimens of 30 embryos, 30 pre-fetuses and 60 human fetuses at the period from the 9th to the 12th weeks of the intrauterine development, which were studied by microscopic examination. Three-dimensional computer reconstructions of the human pre-fetal head were made. Results: During the 7th week of development the maxillary processes maximum approach the lateral and medial nasal ones; in pre-fetuses 20,0 mm of PCL they join the frontal spindle forming the facial structures (upper jaw and lip, vestibule of the oral cavity, rudiments of dental laminas, and rudiments of dental buds in its distal portions). Osteogenous islets, rudiments of the mimic and masticatory muscles, blood vessels are formed. During the 8th week of development the osseous tissue of the mandible is formed, the alveolar processes are formed. The oral and nasal cavities are isolated in 9-10-week pre-fetuses, the mass of the osseous tissue increases in both jaws, the enamel organs are detached, the angles and rami formed by the hyaline cartilaginous tissue of the mandible are determined, the rudiments of the temporomandibular joints are already seen. During the 11th week of development the osseous base of both jaws become formed. Till the end of the 12th week the osseous tissue begins to replace the hyaline cartilage of the mandibular rami, and the articular heads are formed in the portion of their proximal ends. Conclusions: The mandible in its development is known to be characterized by intra-cartilaginous formation of the bone which starts from the ends of the cartilage gradually displaced by the osseous tissue. It is indicated that both jaws in pre-fetuses 37,0 and 42,0 mm of PCL are presented by the typical cartilaginous tissue, and in pre-fetuses 45,0-50,0 mm of PCL the osseous tissue is already available replacing the cartilaginous one.