Structural and Molecular Kinetic Features of Activities of DNA Polymerases
Copyright policy )Structural and Molecular Kinetic Features of Activities of DNA Polymerases
DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis.
- Novosibirsk State University Russian Federation
- Department of Biological Sciences Russian Federation
- Institute of Chemical Biology and Fundamental Medicine Russian Federation
- Siberian Branch of the Russian Academy of Sciences Russian Federation
DNA Replication, Kinetics, DNA Repair, Humans, Review, DNA, DNA-Directed DNA Polymerase, Phylogeny
DNA Replication, Kinetics, DNA Repair, Humans, Review, DNA, DNA-Directed DNA Polymerase, Phylogeny
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