Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype
Copyright policy )Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype
Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor alpha (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP was associated with EHS in the Japanese population. We found a significant association with EHS patients possessing the HLA-DRB1*1501-DQB1*0602 haplotype, compared with HLA-matched healthy individuals (P(allele)=0.008; P(positivity)=5 x 10(-4)), whereas no significant association was observed for EHS patients without this haplotype. Thus, TCRA is a plausible candidate for susceptibility to EHS patients positive for the HLA-DRB1*1501-DQB1*0602 haplotype.
- University of Tokyo Japan
- Stanford University United States
- Neuropsychiatric Research Institute United States
- Tokyo Medical University Japan
- Tokyo Institute of Psychiatry Japan
Genetic Markers, Receptors, Antigen, T-Cell, alpha-beta, Disorders of Excessive Somnolence, HLA-DR Antigens, Polymorphism, Single Nucleotide, Haplotypes, Japan, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, HLA-DRB1 Chains
Genetic Markers, Receptors, Antigen, T-Cell, alpha-beta, Disorders of Excessive Somnolence, HLA-DR Antigens, Polymorphism, Single Nucleotide, Haplotypes, Japan, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, HLA-DRB1 Chains
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