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Cancer Science
Article . 2011 . Peer-reviewed
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Cancer Science
Article
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Cancer Science
Article . 2012
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Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Authors: Seiji Ito; Keitaro Matsuo; Miki Watanabe; Yasushi Yatabe; Hideo Tanaka; Akira Sawaki; Hidemi Ito; +7 Authors

Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Abstract

The insulin‐like growth factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. Although the association between IGF1 gene polymorphisms and cancer risk has been evaluated for several carcinomas, this association has not yet been examined for stomach cancer. We investigated the association between IGF1 polymorphisms and the risk of stomach cancer in a Japanese population. A total of 703 patients with stomach cancer and 1462 non‐cancer control subjects were enrolled in this case–control study. Associations between polymorphisms of 10 IGF1 loci and the risk of stomach cancer were evaluated using odds ratios (OR) and 95% confidence intervals (CI) in multiple logistic regression models. We observed that the C allele in rs1520220 and the G allele in rs4764887 were significantly associated with stomach cancer risk in the per‐allele model after adjusting for other risk factors (OR: 1.14 [95% CI: 1.00–1.30] and OR: 1.18 [95% CI: 1.02‐1.36], respectively). We also observed a positive and dose‐dependent association between the number of risk alleles and stomach cancer risk (P‐trend: 0.019) when examining the two loci in the same model. These associations were still seen after adjusting for potential confounders, including sex, age, smoking status, history of diabetes and family history of stomach cancer. We did not find any significant interaction between these factors and the number of risk alleles. In conclusion, we observed a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of IGF1 is warranted. (Cancer Sci 2011; 102: 2231–2235)

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Keywords

Adult, Aged, 80 and over, Male, Genotype, Middle Aged, Polymorphism, Single Nucleotide, Japan, Risk Factors, Stomach Neoplasms, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Insulin-Like Growth Factor I, Aged, Signal Transduction

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Average
gold