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Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 02 Jun 2010 China (People's Republic of) Publisher:Springer Science and Business Media LLCJournal:BMC Medical Genetics, volume 11 (eissn: 1471-2350,

Authors: Wen Guo Fan; Xiao-Feng Zhu; Dong Pei Li; Jian Qing Huang; Hsiang-Fu Kung; Jin Long Wang; Marie C.M. Lin; +2 Authors

doi: 10.1186/1471-2350-11-83

pmid: 20525207

pmc: PMC2901214

handle: 10722/124533

Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population

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Abstract

Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs17840762, rs17840761, rs11355458) and in the 3' untranslated region (UTR) (rs16927997, rs1140763, rs12009) and possible risk of chronic HBV infection were assessed in a case-control study. 496 cases and 539 individually matched healthy controls were genotyped.Overall, no associations were observed in genotypic analyses. In addition, haplotypes and diplotypes combining those SNPs in the promoter or in the 3' UTR in high linkage disequilibrium (LD) were also not associated with HBV risk.These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population.

Country

China (People's Republic of)

Related Organizations

Sun Yat-sen University
China (People's Republic of)
Chinese University of Hong Kong
China (People's Republic of)
University of Hong Kong
China (People's Republic of)
University of Hong Kong (香港大學)
China (People's Republic of)
Hospital Authority
China (People's Republic of)

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Keywords

570, Hepatitis B virus, Genotype, Chronic - genetics, QH426-470, Regulatory Sequences, Nucleic Acid, Infections, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Hepatitis B, Chronic - genetics, Hepatitis B, Chronic, Genetic, Asian People, Population Groups, Genetics, Humans, Genetics(clinical), HSP70 Heat-Shock Proteins, Polymorphism, Internal medicine, 3' Untranslated Regions, Endoplasmic Reticulum Chaperone BiP, Polymorphism, Genetic, Membrane Proteins, Hepatitis B, RC31-1245, Asian Continental Ancestry Group - genetics, Hepatitis B - genetics, Haplotypes, Case-Control Studies, Viruses, Disease Susceptibility, Research Article

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