Prep2: Cloning and expression of a new prep family member
Copyright policy )Prep2: Cloning and expression of a new prep family member
AbstractWe describe Prep2, a new murine homeobox‐containing gene closely related to Prep1. The PREP2 protein belongs to the three amino acid loop extension (TALE) superclass of homeodomain‐containing proteins and encodes a polypeptide of 462 residues. As for PREP1, PREP2 binds an appropriate site on DNA as a heterodimer with PBX1A. Northern analysis, immunoblotting, immunohistochemistry, and in situ hybridization show widespread Prep2 expression during organogenesis and in the adult. The data suggest that Prep2 functions to varying degrees in a broad array of tissues and developmental processes. © 2002 Wiley‐Liss, Inc.
- McGill University Canada
Homeodomain Proteins, Mice, Sequence Homology, Amino Acid, Organogenesis, Molecular Sequence Data, Animals, Gene Expression Regulation, Developmental, Cloning, Molecular, Transcription Factors
Homeodomain Proteins, Mice, Sequence Homology, Amino Acid, Organogenesis, Molecular Sequence Data, Animals, Gene Expression Regulation, Developmental, Cloning, Molecular, Transcription Factors
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