Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice
Copyright policy )Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice
GlutathioneS-transferases (GSTs) are an important family of multifunctional enzymes that play a role in the protection of tissues by the detoxification of hazardous and carcinogenic compounds. We found previously thatGstm6is upregulated in the somatic cells of male mouse fetal gonads relative to female gonads. In this study, we describe the spatial and temporal expression pattern ofGstm6during mouse development. We show thatGstm6is predominantly expressed in the reproductive system, at significantly higher levels in XY gonads compared with XX gonads from 11.5 dpc onwards, and remains expressed in the testes in adult mice. Its expression is associated with the Sertoli cell lineage, and is dependent on the expression of the male sex-determining geneSox9. Our data suggest thatGstm6plays a male-specific role in gonad development or function, possibly by modulating the exposure of somatic tissue and/or germ cells to endogenous or exogenous toxicants.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- University of Melbourne Australia
- Prince Henry's Institute of Medical Research Australia
Male, proliferation, Mice, Transgenic, mullerian hormone gene, Mice, granulosa, C1, SRY, Testis, Animals, In Situ Hybridization, Glutathione Transferase, Sertoli Cells, mouse testis, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Ovary, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, differentiation, 06 Biological Sciences, Mice, Inbred C57BL, sex determination reveals, 970106 Expanding Knowledge in the Biological Sciences, Female, candidate genes, transcription, SOX9
Male, proliferation, Mice, Transgenic, mullerian hormone gene, Mice, granulosa, C1, SRY, Testis, Animals, In Situ Hybridization, Glutathione Transferase, Sertoli Cells, mouse testis, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Ovary, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, differentiation, 06 Biological Sciences, Mice, Inbred C57BL, sex determination reveals, 970106 Expanding Knowledge in the Biological Sciences, Female, candidate genes, transcription, SOX9
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