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Biochemical and Biophysical Research Communications
Article . 2003 . Peer-reviewed
License: Elsevier TDM
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Biochemical and Biophysical Research Communications
Article . 2003
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Biochemical and Biophysical Research Communications
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Fibroblast growth factor 10 is required for proper development of the mouse whiskers

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2003 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 302, pages 562-567 (issn: 0006-291X, Copyright policy )
Authors: Katsuhiko Ono; Shigeaki Kato; Kazuyo Ohata; Nobuyuki Itoh; Hirotaka Tao; Sumihare Noji; Hideyo Ohuchi;

doi: 10.1016/s0006-291x(03)00183-9

pmid: 12615071

Fibroblast growth factor 10 is required for proper development of the mouse whiskers

Abstract

Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.

Related Organizations
Keywords

Mice, Knockout, Time Factors, Mice, Transgenic, Fibroblast Growth Factors, Mesoderm, Mice, Phenotype, Vibrissae, Microscopy, Electron, Scanning, Trans-Activators, Animals, Hedgehog Proteins, Fibroblast Growth Factor 10, Signal Transduction

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Top 10%
Top 10%
Top 10%
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