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Expression homeostasis during DNA replication

descriptionPublicationkeyboard_double_arrow_right Article 04 Mar 2016 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 351, pages 1,087-1,090 (issn: 0036-8075, eissn: 1095-9203,

Authors: Y. Voichek; R. Bar-Ziv; N. Barkai;

doi: 10.1126/science.aad1162

pmid: 26941319

Expression homeostasis during DNA replication

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Abstract

Doubling DNA but not expression As the genome replicates, and before the cell divides, the copy number of the replicated portions of the genome doubles. In bacteria and archaea, gene expression tracks with gene dosage, both of which increase after DNA replication. Voichek et al. , however, show that an increase in DNA dosage after replication does not increase gene expression in budding yeast. This expression buffering is mediated by the acetylation of newly synthesized histone H3 deposited on the replicated DNA. This acetylation helps suppress transcription from the excess DNA. Science , this issue p. 1087

Related Organizations

Weizmann Institute of Science
Israel

Keywords

DNA Replication, Saccharomyces cerevisiae Proteins, Gene Dosage, Acetylation, Cell Cycle Proteins, RNA, Fungal, DNA-Directed RNA Polymerases, Saccharomyces cerevisiae, Templates, Genetic, Genomic Instability, S Phase, Histones, Gene Expression Regulation, Fungal, Homeostasis, RNA, Messenger, Genome, Fungal, Histone Acetyltransferases, Molecular Chaperones

2 Research products, page 1 of 1

Histone acetyltransferase RTT109
2017IsRelatedTo
Protein TOS4
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	95
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%