Mice Deficient in Nervous System-specific Carbohydrate Epitope HNK-1 Exhibit Impaired Synaptic Plasticity and Spatial Learning
Copyright policy )Mice Deficient in Nervous System-specific Carbohydrate Epitope HNK-1 Exhibit Impaired Synaptic Plasticity and Spatial Learning
The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P). We generated mice with a targeted deletion of the GlcAT-P gene. The GlcAT-P -/- mice exhibited normal development of gross anatomical features, but the adult mutant mice exhibited reduced long term potentiation at the Schaffer collateral-CA1 synapses and a defect in spatial memory formation. This is the first evidence that the loss of a single non-reducing terminal carbohydrate residue attenuates brain higher functions.
- Kobe University Japan
- University of Tokyo Japan
- Takeda (Japan) Japan
- Kyoto University Japan
- Shimane University Japan
Behavior, Animal, Carbohydrates, Brain, Hippocampus, Immunohistochemistry, Nervous System, Electrophysiology, Mice, Inbred C57BL, Epitopes, Mice, CD57 Antigens, Microscopy, Fluorescence, Memory, Synapses, Mutagenesis, Site-Directed, Animals, Learning, Glycolipids, Gene Deletion, Glycoproteins
Behavior, Animal, Carbohydrates, Brain, Hippocampus, Immunohistochemistry, Nervous System, Electrophysiology, Mice, Inbred C57BL, Epitopes, Mice, CD57 Antigens, Microscopy, Fluorescence, Memory, Synapses, Mutagenesis, Site-Directed, Animals, Learning, Glycolipids, Gene Deletion, Glycoproteins
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