Activity of Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA) Towards 6‐Chloropurine Nucleosides Modified in the Ribose Moiety

descriptionPublicationkeyboard_double_arrow_right Article 13 Oct 2004 Italy English Publisher:WileyJournal:European Journal of Organic Chemistry, volume 2,004, pages 4,405-4,409 (issn: 1434-193X, eissn: 1099-0690,

Copyright policy )

Authors: P.Ciuffreda; B.Buzzi; L. Alessandrini; E. Santaniello;

doi: 10.1002/ejoc.200400380

handle: 2434/5319

Activity of Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA) Towards 6‐Chloropurine Nucleosides Modified in the Ribose Moiety

- Summary
- Subjects
- Related research
  (17)
- Metrics

Abstract

AbstractThe enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐O‐isopropylidene derivative, but show no activity towards the 3,4‐O‐isopropylidene‐1‐methylriboside of 6‐chloropurine and adenine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

Country

Italy

Related Organizations

University of Milan
Italy

Keywords

Biotransformations; Deamination; Enzyme catalysis; Nucleosides

17 Research products, page 1 of 2

Relationship between E3 SUMO-protein Ligase NSE2 (NSMCE2) with Ecto-5'-nucleotidase, ADA and AMPDA Enzymes in Patients with Atherosclerosis
2015IsAmongTopNSimilarDocuments
ChemInform Abstract: The Design and Synthesis of Inhibitors of Adenosine 5′‐Monophosphate Deaminase.
1999IsAmongTopNSimilarDocuments
Stereoselective adenylate deaminase (5′-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5′-alkyl substituted adenosines: a comparison with the action of adenosine deaminase (ADA)
2004IsAmongTopNSimilarDocuments
AMP Deaminase Inhibitors. 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5‘-Monophosphate Mimetics
2000IsAmongTopNSimilarDocuments
AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series
2001IsAmongTopNSimilarDocuments
Muscle purine nucleotide cycle enzymes in exercise intolerance
1997IsAmongTopNSimilarDocuments
The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia
2015IsAmongTopNSimilarDocuments
Plasma Uridine as well as Uric Acid is Elevated Following Fructose Loading
1997IsAmongTopNSimilarDocuments
AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues
2000IsAmongTopNSimilarDocuments
Effects of deoxycoformycin in mice. II. Differences between the drug sensitivities and purine metabolizing enzymes of transplantable lymphomas of varying immunologic phenotypes.
1984IsAmongTopNSimilarDocuments

chevron_left
1
2
chevron_right

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	8
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average