Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice
Copyright policy )Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice
The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II A β b gene in embryonic stem cells, mice were generated that lack cell surface expression of class II molecules. These MHC class II-deficient mice were depleted of mature CD4 + T cells and were deficient in cell-mediated immune responses. These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4 + T cells.
- Harvard University United States
- University of Veterinary Medicine Hungary
Male, Immunity, Cellular, Stem Cells, Genes, MHC Class II, Immunologic Deficiency Syndromes, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Embryo, Mammalian, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Immunoglobulin M, T-Lymphocyte Subsets, Immunoglobulin G, CD4 Antigens, Animals, Female, Crosses, Genetic
Male, Immunity, Cellular, Stem Cells, Genes, MHC Class II, Immunologic Deficiency Syndromes, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Embryo, Mammalian, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Immunoglobulin M, T-Lymphocyte Subsets, Immunoglobulin G, CD4 Antigens, Animals, Female, Crosses, Genetic
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