SCNN1, an Epithelial Cell Sodium Channel Gene in the Conserved Linkage Group on Mouse Chromosome 6 and Human Chromosome 12
Copyright policy )SCNN1, an Epithelial Cell Sodium Channel Gene in the Conserved Linkage Group on Mouse Chromosome 6 and Human Chromosome 12
SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 +/- 2.1)-Scnn1, Vwf-(1.9 +/- 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt).
- University of Michigan United States
- University of Lausanne Switzerland
- University of Michigan–Flint United States
- University of Michigan–Ann Arbor United States
Chromosomes, Human, Pair 12, Genetic Linkage, Science, Molecular, Chromosomes, Epithelium, Sodium Channels, Rats, Mice, Inbred C57BL, Mice, Biological Chemistry, Health Sciences, Genetics, Animals, Humans, Cellular and Developmental Biology
Chromosomes, Human, Pair 12, Genetic Linkage, Science, Molecular, Chromosomes, Epithelium, Sodium Channels, Rats, Mice, Inbred C57BL, Mice, Biological Chemistry, Health Sciences, Genetics, Animals, Humans, Cellular and Developmental Biology
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