IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
Copyright policy )IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
Recurrent pathogenic mutations in IDH1 and IDH2 at the conserved amino acid sites IDH1-R132, IDH2-R140 and IDH2-R172 occur in ~20% of patients with acute myeloid leukemia (AML).1 A recent analysis of AML patients at our institution identified IDH1/2 mutations in 20% (n=167) of 826 AML patients, with IDH1/2 mutations occurring most frequently in the setting of diploid karyotype or other intermediate-risk cytogenetics, particularly trisomy 8 (77 vs 53%, P<0.0005). AML patients with IDH1/2 mutations were overall less likely to have a diagnosis of therapy-related AML (8 vs 17%, P=0.003).2
- The University of Texas MD Anderson Cancer Center United States
Adult, Aged, 80 and over, Male, Adolescent, Middle Aged, Prognosis, Article, Isocitrate Dehydrogenase, Survival Rate, Young Adult, Myelodysplastic Syndromes, Mutation, Biomarkers, Tumor, Disease Progression, Humans, Female, Aged, Follow-Up Studies, Neoplasm Staging
Adult, Aged, 80 and over, Male, Adolescent, Middle Aged, Prognosis, Article, Isocitrate Dehydrogenase, Survival Rate, Young Adult, Myelodysplastic Syndromes, Mutation, Biomarkers, Tumor, Disease Progression, Humans, Female, Aged, Follow-Up Studies, Neoplasm Staging
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).103 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!