Absence of Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis in an Italian Population
Copyright policy )Absence of Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis in an Italian Population
Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an Italian population. No significant association was found between AD and MCC genotypes. These data suggest that <i>Bst</i>XI MCC polymorphism may not be involved in AD.
- Sapienza University of Rome Italy
- Roma Tre University Italy
- University of L'Aquila Italy
Adult, Male, Adolescent, Serine Endopeptidases, Genetic Variation, Infant, Nucleic Acid Hybridization, Middle Aged, Dermatitis, Atopic, Chymases, Italy, Child, Preschool, Humans, Female, Mast Cells, Child, Aged
Adult, Male, Adolescent, Serine Endopeptidases, Genetic Variation, Infant, Nucleic Acid Hybridization, Middle Aged, Dermatitis, Atopic, Chymases, Italy, Child, Preschool, Humans, Female, Mast Cells, Child, Aged
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