A 43-year-old white woman with a history of epidermolysis bullosa simplex (EBS), Weber-Cockayne type (EBSWC), which she had had since childhood, presented with multiple blisters, erosions, and crusts on the bottom of both feet (Figure1). During most of her life, new blisters would arise and then heal after several weeks. Severe flares would occur during the summer months and on vacations to warm climates. Previous treatments included aluminum chloride and tetracycline. The patient’s mother, sister, and son also had a history of EBS-WC. Her medical history was otherwise unremarkable. The only medication she was taking was an oral contraceptive pill, and she reported a drug allergy to penicillin. Physical examination revealed a total of 17 blisters and erosions measuring 0.5 to 3.0 cm on the plantar aspect of the feet. The hands and the rest of the skin were clear. A lesion had previously been biopsied, and the findings confirmed a diagnosis of EBS-WC.