Acetylcholine Synthesis and Accumulation in the CNS of Drosophila Larvae: Analysis of shibirets, a Mutant with a Temperature‐Sensitive Block in Synaptic Transmission
Copyright policy )Acetylcholine Synthesis and Accumulation in the CNS of Drosophila Larvae: Analysis of shibirets, a Mutant with a Temperature‐Sensitive Block in Synaptic Transmission
Abstract: A radiochemical method is applied to the study of neurotransmitter metabolism in Drosophila. The larval CNS is a favorable system for analyzing acetylcholine (ACh) metabolism, since the pool of [3H]ACh rapidly reaches a steady state with a high ratio of intracellular [3H]ACh to [3H]choline. A temperature‐sensitive paralytic mutant, shibirets, shows reduced [3H]ACh accumulation at the restrictive temperature. This reduction is not the result of decreased synthesis of [3H]ACh, but rather an abnormally rapid rate of release, which is not prevented by blocking tetrodotoxin‐sensitive nerve activity.
- University of Iowa United States
Temperature, Brain, Synaptic Transmission, Acetylcholine, Choline, Kinetics, Drosophila melanogaster, Larva, Mutation, Acetylcholinesterase, Animals
Temperature, Brain, Synaptic Transmission, Acetylcholine, Choline, Kinetics, Drosophila melanogaster, Larva, Mutation, Acetylcholinesterase, Animals
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