Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder
Copyright policy )Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder
Blocking mTORC1 rescues the neural progenitor cell migratory defect caused by depletion of the STRADA pseudokinase and reduces seizures in patients with a rare neurodevelopmental disorder.
- Lancaster General Hospital United States
- Clinic for Special Children United States
- University of Groningen Netherlands
- Franklin & Marshall College United States
- University of Pennsylvania United States
ASTROCYTOMAS, MIGRATION, Blotting, Western, Mechanistic Target of Rapamycin Complex 1, Piperazines, PATHWAY, ACTIVATION, Mice, Cell Movement, Central Nervous System Diseases, Pregnancy, Seizures, KINASE, Animals, Humans, TUBEROUS SCLEROSIS COMPLEX, EPILEPSY, Cells, Cultured, Sirolimus, MTOR, TOR Serine-Threonine Kinases, Cytarabine, Imidazoles, MOUSE MODEL, DEVELOPMENTAL BRAIN MALFORMATIONS, Immunohistochemistry, Multiprotein Complexes, Female
ASTROCYTOMAS, MIGRATION, Blotting, Western, Mechanistic Target of Rapamycin Complex 1, Piperazines, PATHWAY, ACTIVATION, Mice, Cell Movement, Central Nervous System Diseases, Pregnancy, Seizures, KINASE, Animals, Humans, TUBEROUS SCLEROSIS COMPLEX, EPILEPSY, Cells, Cultured, Sirolimus, MTOR, TOR Serine-Threonine Kinases, Cytarabine, Imidazoles, MOUSE MODEL, DEVELOPMENTAL BRAIN MALFORMATIONS, Immunohistochemistry, Multiprotein Complexes, Female
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