5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription
Copyright policy )5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription
Although the roles of 5-methylcytosine and 5-hydroxymethylcytosine in epigenetic regulation of gene expression are well established, the functional effects of 5-formylcytosine and 5-carboxylcytosine on the process of transcription are not clear. Here we report a systematic study of the effects of five different forms of cytosine in DNA on mammalian and yeast RNA polymerase II transcription, providing new insights into potential functional interplay between cytosine methylation status and transcription.
- University of Chicago United States
- UNIVERSITY OF CHICAGO
- University of Chicago United States
- University of Chicago United States
- University of California, San Diego United States
Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, Transcription, Genetic, Molecular Sequence Data, RNA, Fungal, DNA, Article, Epigenesis, Genetic, Substrate Specificity, Cytosine, Kinetics, Catalytic Domain, Humans, RNA, Amino Acid Sequence, RNA Polymerase II, DNA, Fungal
Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, Transcription, Genetic, Molecular Sequence Data, RNA, Fungal, DNA, Article, Epigenesis, Genetic, Substrate Specificity, Cytosine, Kinetics, Catalytic Domain, Humans, RNA, Amino Acid Sequence, RNA Polymerase II, DNA, Fungal
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