Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
Copyright policy )Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
The fascinating similarity between the SARS-CoV and SARS-CoV-2, inspires scientific community to investigate deeper into the SARS-CoV proteases such as main protease (Mpro) and papain-like protease (PLpro) and their inhibitors for the discovery of SARS-CoV-2 protease inhibitors. Because of the similarity in the proteases of these two corona viruses, there is a greater chance for the previous SARS-CoV Mpro and PLpro inhibitors to provide effective results against SARS-CoV-2. In this context, the molecular fragments from the SARS-CoV protease inhibitors through the fragment-based drug design and discovery technique can be useful guidance for COVID-19 drug discovery. Here, we have focused on the structure-activity relationship studies of previous SARS-CoV protease inhibitors and discussed about crucial fragments generated from previous SARS-CoV protease inhibitors important for the lead optimization of SARS-CoV-2 protease inhibitors. This study surely offers different strategic options of lead optimization to the medicinal chemists to discover effective anti-viral agent against the devastating disease, COVID-19.
- Dr. Hari Singh Gour University India
- Jadavpur University India
Pharmacology, Molecular Structure, SARS-CoV-2, Organic Chemistry, Coronavirus Papain-Like Proteases, General Medicine, Review Article, Cysteine Proteinase Inhibitors, Antiviral Agents, Molecular Docking Simulation, Structure-Activity Relationship, Severe acute respiratory syndrome-related coronavirus, Drug Design, Drug Discovery, Coronavirus 3C Proteases, Protein Binding
Pharmacology, Molecular Structure, SARS-CoV-2, Organic Chemistry, Coronavirus Papain-Like Proteases, General Medicine, Review Article, Cysteine Proteinase Inhibitors, Antiviral Agents, Molecular Docking Simulation, Structure-Activity Relationship, Severe acute respiratory syndrome-related coronavirus, Drug Design, Drug Discovery, Coronavirus 3C Proteases, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).28 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!