Smads as transcriptional co-modulators
Copyright policy )Smads as transcriptional co-modulators
The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression.
- Mount Sinai Hospital Canada
- Mount Sinai Hospital United States
- University of Toronto Canada
- Mount Sinai Health System United States
- Lunenfeld-Tanenbaum Research Institute Canada
Cell Nucleus, Transcription, Genetic, Serine Endopeptidases, Intracellular Signaling Peptides and Proteins, DNA-Binding Proteins, Transforming Growth Factor beta, Trans-Activators, Animals, Humans, Drosophila, Carrier Proteins, Ubiquitins, Signal Transduction, Smad4 Protein
Cell Nucleus, Transcription, Genetic, Serine Endopeptidases, Intracellular Signaling Peptides and Proteins, DNA-Binding Proteins, Transforming Growth Factor beta, Trans-Activators, Animals, Humans, Drosophila, Carrier Proteins, Ubiquitins, Signal Transduction, Smad4 Protein
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