YY1 Transcription Factor Down-regulates Expression of CCR5, a Major Coreceptor for HIV-1
Copyright policy )YY1 Transcription Factor Down-regulates Expression of CCR5, a Major Coreceptor for HIV-1
Expression of CCR5, a major coreceptor for human immunodeficiency virus type 1 (HIV-1), is regulated by a number of transcription factors. Here we report that the YY1 transcription factor down-regulates CCR5 promoter activity and that overexpression of YY1 reduces cell surface CCR5 expression and infectibility by R5-HIV-1. Because YY1 also down-regulates promoter activities of CXCR4, another major coreceptor for HIV-1 and HIV-1 long terminal repeat, this transcription factor may play a critical role in the pathogenesis of HIV-1 disease.
- Nagasaki University Japan
- Nagasaki University Hospital Japan
Base Sequence, Receptors, CCR5, Down-Regulation, Flow Cytometry, Transfection, Virus Replication, HIV-1, Erythroid-Specific DNA-Binding Factors, Humans, YY1 Transcription Factor, DNA Primers, Plasmids, Transcription Factors
Base Sequence, Receptors, CCR5, Down-Regulation, Flow Cytometry, Transfection, Virus Replication, HIV-1, Erythroid-Specific DNA-Binding Factors, Humans, YY1 Transcription Factor, DNA Primers, Plasmids, Transcription Factors
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