PSCA and Oct-4 Expression in the Benign and Malignant Lesions of Gallbladder: Implication for Carcinogenesis, Progression, and Prognosis of Gallbladder Adenocarcinoma
Copyright policy )PSCA and Oct-4 Expression in the Benign and Malignant Lesions of Gallbladder: Implication for Carcinogenesis, Progression, and Prognosis of Gallbladder Adenocarcinoma
PSCA and Oct-4 have been thought as markers of cancer stem cells. Although overexpression of PSCA and Oct-4 in cancer has been reported, little is known about the clinical and pathological significance with PSCA and Oct-4 expression in gallbladder adenocarcinoma. In this study, overexpression of PSCA and Oct-4 was detected in gallbladder adenocarcinoma (54.6% and 55.6%). Less expression of PSCA and Oct-4 was detected in the pericancerous tissues (19.6% and 21.7%), gallbladder polyps (13.3% and 13.3%), and gallbladder epithelium with chronic cholecystitis (14.3% and 14.3%). The overexpression of PSCA and Oct-4 was significantly associated with differentiation, tumor mass, lymph node metastasis, invasion of gallbladder adenocarcinoma, and decreased overall survival. Our study suggested that overexpression of PSCA and Oct-4 might be closely related to the carcinogenesis, progression, metastasis, or invasive potential and prognosis of gallbladder carcinoma.
- Third Xiangya Hospital China (People's Republic of)
- Central South University China (People's Republic of)
- Second Xiangya Hospital of Central South University China (People's Republic of)
Male, Carcinogenesis, Kaplan-Meier Estimate, Adenocarcinoma, Middle Aged, GPI-Linked Proteins, Prognosis, Neoplasm Proteins, Antigens, Neoplasm, Multivariate Analysis, Disease Progression, Humans, Female, Gallbladder Neoplasms, Octamer Transcription Factor-3, Research Article, Proportional Hazards Models
Male, Carcinogenesis, Kaplan-Meier Estimate, Adenocarcinoma, Middle Aged, GPI-Linked Proteins, Prognosis, Neoplasm Proteins, Antigens, Neoplasm, Multivariate Analysis, Disease Progression, Humans, Female, Gallbladder Neoplasms, Octamer Transcription Factor-3, Research Article, Proportional Hazards Models
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