The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry
Copyright policy )The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry
In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.
- Salk Institute for Biological Studies United States
- Regeneron (United States) United States
- Scripps Research Institute United States
Homeodomain Proteins, Fibroblast Growth Factor 8, Nodal Protein, Left-Right Determination Factors, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Proteins, Chick Embryo, Avian Proteins, Fibroblast Growth Factors, Bone Morphogenetic Proteins, COS Cells, Animals, Humans, Intercellular Signaling Peptides and Proteins, Hedgehog Proteins, Amino Acid Sequence, Cloning, Molecular, Body Patterning
Homeodomain Proteins, Fibroblast Growth Factor 8, Nodal Protein, Left-Right Determination Factors, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Proteins, Chick Embryo, Avian Proteins, Fibroblast Growth Factors, Bone Morphogenetic Proteins, COS Cells, Animals, Humans, Intercellular Signaling Peptides and Proteins, Hedgehog Proteins, Amino Acid Sequence, Cloning, Molecular, Body Patterning
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).207 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!