Selective DNA‐Binding by Designed Bisbenzamidine‐Homeodomain Chimeras
Copyright policy )Selective DNA‐Binding by Designed Bisbenzamidine‐Homeodomain Chimeras
AbstractWe report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor‐groove DNA binders. The hybrid featuring the sequence of the native protein failed to bind to DNA; however, modifications that increased the α‐helical folding propensity of the peptide allowed specific DNA binding by a bipartite (major/minor groove) interaction.
Homeodomain Proteins, Models, Molecular, DNA recognition, Binding Sites, Molecular Structure, Oligonucleotides, DNA, :Investigación::23 Química::2302 Bioquímica [Materias], Protein Structure, Secondary, Benzamidines, Materias::Investigación::23 Química::2302 Bioquímica, Molecular recognition, Peptides, Supramolecular chemistry
Homeodomain Proteins, Models, Molecular, DNA recognition, Binding Sites, Molecular Structure, Oligonucleotides, DNA, :Investigación::23 Química::2302 Bioquímica [Materias], Protein Structure, Secondary, Benzamidines, Materias::Investigación::23 Química::2302 Bioquímica, Molecular recognition, Peptides, Supramolecular chemistry
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