Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions
Copyright policy )Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions
We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation. Moreover, in HTR-8/SVneo cells, considered a good model of first-trimester EVT, SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2.
Cell proliferation; Cyclic AMP; Migration; Phospholipase A2; Somatostatin; Trophoblast-derived cell lines;, Cell Differentiation, Trophoblasts, Pregnancy Trimester, First, Pregnancy, Cyclic AMP, Humans, Female, Receptors, Somatostatin, Somatostatin, Cells, Cultured, Cell Proliferation
Cell proliferation; Cyclic AMP; Migration; Phospholipase A2; Somatostatin; Trophoblast-derived cell lines;, Cell Differentiation, Trophoblasts, Pregnancy Trimester, First, Pregnancy, Cyclic AMP, Humans, Female, Receptors, Somatostatin, Somatostatin, Cells, Cultured, Cell Proliferation
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