Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development
Copyright policy )Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development
Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as alpha3beta1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that alpha3beta1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of beta1 integrin in a reelin-dependent manner. Thus, alpha3beta1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.
- Harvard University United States
- University of North Carolina at Chapel Hill United States
- University of North Carolina System United States
Cerebral Cortex, Recombination, Genetic, Extracellular Matrix Proteins, Cell Adhesion Molecules, Neuronal, Blotting, Western, Serine Endopeptidases, Integrin alpha3beta1, Nerve Tissue Proteins, Mice, Reelin Protein, Cell Movement, Pregnancy, Mutation, Animals, Immunoprecipitation, Female, Cues, Protein Binding
Cerebral Cortex, Recombination, Genetic, Extracellular Matrix Proteins, Cell Adhesion Molecules, Neuronal, Blotting, Western, Serine Endopeptidases, Integrin alpha3beta1, Nerve Tissue Proteins, Mice, Reelin Protein, Cell Movement, Pregnancy, Mutation, Animals, Immunoprecipitation, Female, Cues, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).76 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!