Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection
Copyright policy )Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection
ABSTRACT Recombinant green fluorescent protein encoding Kaposi's sarcoma-associated herpesvirus (rKSHV.152) infection of β-estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ΔB-Raf [FF] :ER (expressing a weaker form of B-Raf) could be enhanced to levels comparable to that of HFF/ΔB-Raf [DD] :ER cells by pretreating cells with soluble vascular endothelial growth factor (VEGF). Conversely, VEGF expression and infection efficiency typically observed in β-estradiol stimulated HFF/ΔB-Raf [DD] :ER cells could be lowered significantly by treating with VEGF small interfering RNA. In addition, we observed enhancement of the KSHV infection in HFF cells transfected with human VEGF 121 . These results confirm the ability of Raf-induced VEGF to augment KSHV infection of cells.
- University of Pittsburgh United States
- University of North Carolina System United States
- East Carolina University United States
- University of Pittsburgh Cancer Institute United States
Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Human herpes virus 8, Herpesvirus 8, Human, Kaposi’s sarcoma-associated herpes virus, Humans, raf Kinases, Vascular endothelial growth factor, RNA, Small Interfering, Cells, Cultured
Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Human herpes virus 8, Herpesvirus 8, Human, Kaposi’s sarcoma-associated herpes virus, Humans, raf Kinases, Vascular endothelial growth factor, RNA, Small Interfering, Cells, Cultured
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