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Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 26 Apr 2022 English Publisher:American Society for MicrobiologyJournal:mBio, volume 13 (eissn: 2150-7511, Copyright policy )Funded by:EC | NOVRIB
Authors: Giuseppe Cimicata; Gil Fridkin; Tanaya Bose; Zohar Eyal; Yehuda Halfon; Elinor Breiner-Goldstein; Tara Fox; +5 Authors

doi: 10.1128/mbio.00306-22

pmid: 35348349

pmc: PMC9040758

Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis

Abstract

The mechanism that regulates the translocation step in ribosomes during protein synthesis is not fully understood. In this work, cryo-EM techniques used to image ribosomes from Staphylococcus aureus after incubation at physiological temperature allowed the identification of a conformation of the helix 68 that has never been observed so far.

Related Organizations
Keywords

Models, Molecular, protein synthesis, H68, antisense, Cryoelectron Microscopy, translation, Microbiology, QR1-502, ribosome, RNA, Transfer, Protein Biosynthesis, Ribosomes, PNA, Research Article

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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Top 10%
Average
Top 10%
Green
gold
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