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Molecular mechanisms of COPII vesicle formation

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2007 United Kingdom English Publisher:Elsevier BVJournal:Seminars in Cell & Developmental Biology, volume 18, pages 424-434 (issn: 1084-9521,

Authors: Lee, Marcus C.S.; Miller, Elizabeth A.;

doi: 10.1016/j.semcdb.2007.06.007

pmid: 17686639

Molecular mechanisms of COPII vesicle formation

- Summary
- Subjects
- Related research
  (6)
- Metrics

Abstract

The first step in protein secretion from eukaryotic cells is mediated by COPII vesicles, known for the cytoplasmic coat proteins that are the minimal machinery required to generate these small transport carriers. The five COPII coat components coordinate to create a vesicle by locally generating membrane curvature and populating the incipient bud with the appropriate cargo. This review describes the molecular details of how the COPII coat sculpts vesicles from the endoplasmic reticulum and highlights some unresolved questions regarding the regulation of this process in the complex environment of the eukaryotic cell.

Country

United Kingdom

Related Organizations

University of Dundee
United Kingdom
University of Chicago
United States
King’s University
United States

Keywords

Models, Molecular, 570, Cargo capture, Vesicular Transport Proteins, 540, Endoplasmic Reticulum, name=Cell Biology, GTP Phosphohydrolases, name=Developmental Biology, COPII, Animals, Humans, /dk/atira/pure/subjectarea/asjc/1300/1309, COP-Coated Vesicles, Carrier Proteins, /dk/atira/pure/subjectarea/asjc/1300/1307, Protein Processing, Post-Translational, Endoplasmic reticulum, Transport vesicle, Monomeric GTP-Binding Proteins

6 Research products, page 1 of 1

Protein transport protein SEC23
2017IsRelatedTo
Protein transport protein SEC24
2017IsRelatedTo
COPII coat assembly protein SEC16
2017IsRelatedTo
Small COPII coat GTPase SAR1
2017IsRelatedTo
Guanine nucleotide-exchange factor SEC12
2017IsRelatedTo
Protein transport protein SEC13
2017IsRelatedTo

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