Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses
Copyright policy )Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses
In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protection against different strains of influenza virus, including H5 type. To analyze the mechanism of NKT cell activation by this nasal vaccine, we prepared fluorescence-labeled alpha-GalCer by which we detect a direct interaction between NKT cells and alpha-GalCer-stored dendritic cells in nasal mucosa-associated tissues. Accordingly, although very few NKT cells exist at mucosa, the nasal vaccination induced a localized increase in NKT cell population, which is partly dependent on CXCL16/CXCR6. Furthermore, we found that NKT cell activation stimulates mucosal IgA production by a mechanism that is dependent on interleukin (IL)-4 production. These results strengthen the basis of nasal vaccination via NKT cell activation, which can induce immune cross-protection.
Chemokine CXCL6, Influenza A Virus, H5N1 Subtype, Galactosylceramides, Chemokine CXCL16, Dendritic Cells, Cross Reactions, Lymphocyte Activation, Immunoglobulin A, Influenza B virus, Mice, Adjuvants, Immunologic, Antibody Specificity, Influenza A virus, Influenza Vaccines, Influenza, Human, Animals, Humans, Interleukin-4, Administration, Intranasal, Fluorescent Dyes
Chemokine CXCL6, Influenza A Virus, H5N1 Subtype, Galactosylceramides, Chemokine CXCL16, Dendritic Cells, Cross Reactions, Lymphocyte Activation, Immunoglobulin A, Influenza B virus, Mice, Adjuvants, Immunologic, Antibody Specificity, Influenza A virus, Influenza Vaccines, Influenza, Human, Animals, Humans, Interleukin-4, Administration, Intranasal, Fluorescent Dyes
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