Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: Comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
Copyright policy )Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: Comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
We have reported that serum level of soluble HLA-A, -B, -C (sHLA-A,-B,-C) antigens is elevated in HIV-infected subjects and decreases after antiretroviral therapy (HAART). In this study, we measured the levels of soluble HLA-G (sHLA-G) antigens in a cohort of HIV-infected patients before and during HAART. sHLA-G and sHLA-A, -B, -C levels were significantly elevated in HIV-infected subjects as compared with controls before antiretroviral treatment and significantly decreased after 36 months of HAART. sHLA-G levels were correlated with sHLA-A, -B, -C levels, the decrease of plasma HIV-RNA level, the increase of CD4+ T-lymphocyte number and the decrease of CD8+ T-lymphocyte number. These results suggest that the measurement of sHLA-G and sHLA-A, -B, -C antigen serum levels might represent a useful surrogate marker to monitor virological response and immune reconstitution in HIV-positive subjects undergoing HAART treatment.
- Goa University India
- University of Genoa Italy
Adult, HLA-G Antigens, Male, Sex Characteristics, HLA-A Antigens, Histocompatibility Antigens Class I, HIV Infections, HLA-C Antigens, CD8-Positive T-Lymphocytes, Middle Aged, CD4 Lymphocyte Count, HLA Antigens, HLA-B Antigens, Antiretroviral Therapy, Highly Active, HIV-1, Humans, RNA, Viral, Female, Lymphocyte Count, Biomarkers
Adult, HLA-G Antigens, Male, Sex Characteristics, HLA-A Antigens, Histocompatibility Antigens Class I, HIV Infections, HLA-C Antigens, CD8-Positive T-Lymphocytes, Middle Aged, CD4 Lymphocyte Count, HLA Antigens, HLA-B Antigens, Antiretroviral Therapy, Highly Active, HIV-1, Humans, RNA, Viral, Female, Lymphocyte Count, Biomarkers
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