The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production
Copyright policy )The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production
Resisting the Chop Dengue, West Nile, and Yellow Fever viruses are all flaviviruses that have single-stranded RNA genomes and form specific, short flaviviral RNAs (sfRNAs) during infection that cause viral pathogenicity. These sfRNAs are produced by the incomplete degradation of viral RNA by the host-cell exonuclease Xrn1. What stops the host enzyme from completely chopping up the viral RNA? Chapman et al. (p. 307 ) reveal a pseudoknot in the structure of the Xrn1-resistant segment of a sfRNA from Murray Valley Encephalitis Virus, which, perhaps, the host Xrn1 exonuclease cannot untangle.
- Lawrence Berkeley National Laboratory United States
- Colorado State University United States
- Howard Hughes Medical Institute United States
- University of Colorado Denver United States
Models, Molecular, Base Sequence, Molecular Sequence Data, Encephalitis Virus, Murray Valley, Crystallography, X-Ray, Exoribonucleases, Mutation, Nucleic Acid Conformation, RNA, Viral, Base Pairing
Models, Molecular, Base Sequence, Molecular Sequence Data, Encephalitis Virus, Murray Valley, Crystallography, X-Ray, Exoribonucleases, Mutation, Nucleic Acid Conformation, RNA, Viral, Base Pairing
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