This document introduces the Consciousness–Aptamer Interface Standard (CAIS v1.0),a cognitive–physiological measurement framework designed to enhance safety,situational awareness, and collective stability inconnected, shared, and autonomous mobility systems. CAIS integrates: the OE–EE–RE dynamic model, representing ordered, entropic, and relationalpatterns that map directly onto human attention, cognitive load, fatigue,and cooperative behavior on the road, the CFE⁺ Framework, enabling multi-layer evaluation of individual drivers,vehicle–vehicle interactions, and collective traffic dynamics, three quantitative indices—VCE (driver cognitive energy & clarity),CRI (vehicle-to-driver or driver-to-driver resonance & coordination),CFI (collective traffic field coherence and stability), and a biochemical aptamer–iodine sensing interface to capture physiologicalsignals associated with fatigue, stress responses, attentional shifts,and reduced situational awareness. For the AI4CSM community, CAIS supports: real-time driver state monitoring (fatigue, distraction, overload), enhanced safety for connected mobility and shared driving systems, improved V2X communication through behavioral coherence modeling, collective intelligence analysis in urban and highway mobility, integration of consciousness metrics intoautonomous driving decision systems, risk prediction models,and cooperative mobility algorithms, and development of next-generation human–vehicle–collective sensing networks. CAIS establishes a new category of cognitive–physiological sensingfor the automotive and mobility industry, enablingsafer, more adaptive, and more coherent connected mobility ecosystems. ────────────────────────Applied & Modular Discovery IndexConsciousness Civilization Framework (CCF) — Applied & Modular Stackhttps://osf.io/q9krm Canonical Authority & Lineage AnchorConsciousness Civilization Framework (CCF) — Canonical Projecthttps://osf.io/2hgmu OSF Registration DOI10.17605/OSF.IO/2HGMU────────────────────────