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pmid: 9367441
ABSTRACT A signaling pathway active on the ventral side of the Drosophila embryo defines dorsoventral polarity. A cell surface signal relayed by Toll, Tube and Pelle releases the Rel-related protein Dorsal from its cytoplasmic inhibitor Cactus; free Dorsal translocates into nuclei and directs expression of ventral fates. Using the yeast two-hybrid system and immunoprecipitation experiments, we define scaffolding and anchoring interactions among the pathway components. We show that Dorsal binds specifically to Tube, Pelle and Cactus, and that the protein kinase activity of Pelle differentially regulates its interactions with Dorsal and Tube. We also identify Drosophila Filamin as a potential adaptor linking the interaction network, via Tube, to the transmembrane receptor Toll.
Cell Nucleus, Cytoplasm, Embryo, Nonmammalian, Recombinant Fusion Proteins, Nuclear Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, beta-Galactosidase, Models, Biological, DNA-Binding Proteins, Genes, Reporter, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Cloning, Molecular, Protein Kinases, Body Patterning, Signal Transduction, Transcription Factors
Cell Nucleus, Cytoplasm, Embryo, Nonmammalian, Recombinant Fusion Proteins, Nuclear Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, beta-Galactosidase, Models, Biological, DNA-Binding Proteins, Genes, Reporter, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Cloning, Molecular, Protein Kinases, Body Patterning, Signal Transduction, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 88 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |