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Stomatin-Related Olfactory Protein, SRO, Specifically Expressed in the Murine Olfactory Sensory Neurons

descriptionPublicationkeyboard_double_arrow_right Article 15 Jul 2002 English Publisher:Society for NeuroscienceJournal:The Journal of Neuroscience, volume 22, pages 5,931-5,937 (issn: 0270-6474, eissn: 1529-2401,

Authors: Kazunari Miyamichi; Hitoshi Sakano; Akio Tsuboi; Yuichiro Oka; Ko Kobayakawa; Reiko Hayashi; Kenji Morita;

doi: 10.1523/jneurosci.22-14-05931.2002

pmid: 12122055

pmc: PMC6757947

Stomatin-Related Olfactory Protein, SRO, Specifically Expressed in the Murine Olfactory Sensory Neurons

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Abstract

We identified a stomatin-related olfactory protein (SRO) that is specifically expressed in olfactory sensory neurons (OSNs). The mousesrogene encodes a polypeptide of 287 amino acids with a calculated molecular weight of 32 kDa. SRO shares 82% sequence similarity with the murine stomatin, 78% withCaenorhabditis elegansMEC-2, and 77% withC. elegansUNC-1. Unlike other stomatin-family genes, thesrotranscript was present only in OSNs of the main olfactory epithelium. Nosroexpression was seen in vomeronasal neurons. SRO was abundant in most apical dendrites of OSNs, including olfactory cilia. Immunoprecipitation revealed that SRO associates with adenylyl cyclase type III and caveolin-1 in the low-density membrane fraction of olfactory cilia. Furthermore, anti-SRO antibodies stimulated cAMP production in fractionated cilia membrane. SRO may play a crucial role in modulating odorant signals in the lipid rafts of olfactory cilia.

Related Organizations

University of Tokyo
Japan

Keywords

Caveolin 1, Cell Membrane, Molecular Sequence Data, Membrane Proteins, Nerve Tissue Proteins, Blood Proteins, Dendrites, Kidney, Caveolins, Antibodies, Olfactory Receptor Neurons, Cell Line, Isoenzymes, Mice, Olfactory Mucosa, Animals, Humans, Cilia, In Situ Hybridization, Adenylyl Cyclases

15 Research products, page 1 of 2

Caveolin
2017IsRelatedTo
Caveolin-1
2017IsRelatedTo
Adenylate cyclase
2018IsRelatedTo
Caveolin
2017IsRelatedTo
Mus musculus (house mouse) stomatin related olfactory protein SRO
2018IsRelatedTo
Caveolin-1
2017IsRelatedTo
Stomatin-like protein 3
2017IsRelatedTo
Adenylate cyclase 3, isoform CRA_b
2017IsRelatedTo
Adenylate cyclase
2018IsRelatedTo
Adenylyl cyclase 3
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	33
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%