Abstract Objective To evaluate the feasibility and efficacy of computed tomography (CT)‐guided radiofrequency ablation (RFA) of cervical intervertebral discs for the treatment of discogenic cervicogenic headache (CEH). Background Some patients with CEH experience no obvious therapeutic effect after conventional therapy, particularly patients with refractory CEH originating from abnormal cervical intervertebral discs. Treatment for this type of CEH remains poorly characterized. Methods Using a single intervention arm, pretest/posttest design, we retrospectively analyzed the data of patients who underwent CT‐guided RFA of cervical intervertebral discs for CEH at the Pain Medicine Center of Zhejiang Provincial People’s Hospital from January 2017 to April 2021. If conservative treatment failed in patients with discogenic CEH, we classified the patients as having refractory CEH and performed RFA of cervical intervertebral discs. We used a numeric rating scale (NRS) to assess pain intensity for 6 months. We also compared therapeutic outcome of patients with different characteristics. Results A total of 44 patients who underwent CT‐guided RFA of cervical intervertebral discs were enrolled and 41 of them were analyzed in the present study. The preoperative median (25th, 75th) NRS score was 4 (4, 5), and it was significantly reduced to 1 (0, 4) 6 months after RFA ( p < 0.001). The number of patients with ≥50% of their pain relieved after 6 months was 28 of 41 (68%). No serious treatment‐related complications occurred in this study. Compared with single‐level RFA, multi‐level RFA shows greater effects on pain intensity reduction ( p = 0.032) and pain relief rate ( p = 0.047) of patients. Conclusion In patients who have discogenic CEH, CT‐guided RFA of the cervical intervertebral discs appears to be a promising treatment with no serious complications.