Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
Copyright policy )Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.
- Stony Brook University United States
- Yale University United States
- University of Würzburg Germany
Adult, Genetic Markers, Male, Serotonin, Adolescent, Genotype, Mood Disorders, DNA Mutational Analysis, Emotions, Genetic Variation, Neuropsychological Tests, Tryptophan Hydroxylase, Amygdala, Magnetic Resonance Imaging, Mutation, Humans, Female, Genetic Predisposition to Disease, Genetic Testing, Photic Stimulation
Adult, Genetic Markers, Male, Serotonin, Adolescent, Genotype, Mood Disorders, DNA Mutational Analysis, Emotions, Genetic Variation, Neuropsychological Tests, Tryptophan Hydroxylase, Amygdala, Magnetic Resonance Imaging, Mutation, Humans, Female, Genetic Predisposition to Disease, Genetic Testing, Photic Stimulation
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