Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology
Copyright policy )Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology
AbstractGenome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.
- McLaren Health Care United States
- Mayo Clinic United States
- Ministry of Health Malaysia
- University of California System United States
- University of Mary United States
Adult, Male, Heterozygote, Lymphoma, Non-Hodgkin, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Middle Aged, Humans, Female, Alleles, Aged, Genome-Wide Association Study, Retrospective Studies
Adult, Male, Heterozygote, Lymphoma, Non-Hodgkin, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Middle Aged, Humans, Female, Alleles, Aged, Genome-Wide Association Study, Retrospective Studies
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