Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
Copyright policy )Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
AbstractThe potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P. acnes (≤85%, i.e. ≤1 log10 cycle reduction of bacterial viable count). However, the local heat generated upon exciting the functionalized GNR with NIR laser beam has a significant photothermal ablation effect (≥99.99%, i.e. ≥4 log10 cycles reduction of bacterial viable count). Such photothermolysis effect could potentiate the antibacterial activity of GNR, which may call for minimum concentration and side effects of these nanotherapeutics.
- Al-Zaytoonah University of Jordan Jordan
- University of Jordan Jordan
Staphylococcus aureus, Science, Materials Science, Biomedical Engineering, Organic chemistry, Nanorod, FOS: Medical engineering, Article, Engineering, Genetics, Gold Nanoparticles, Nanotechnology, Propionibacterium acnes, Biology, Ethylene glycol, FOS: Nanotechnology, Nanotubes, Bacteria, Q, R, Nanotechnology and Imaging for Cancer Therapy and Diagnosis, Advances in Photoacoustic Imaging and Tomography, Photothermal therapy, Materials science, Anti-Bacterial Agents, Electronic, Optical and Magnetic Materials, Chemistry, FOS: Biological sciences, Physical Sciences, Medicine, Polystyrenes, Gold, Plasmonic Nanoparticles: Synthesis, Properties, and Applications, Antibacterial activity, Hydrophobic and Hydrophilic Interactions
Staphylococcus aureus, Science, Materials Science, Biomedical Engineering, Organic chemistry, Nanorod, FOS: Medical engineering, Article, Engineering, Genetics, Gold Nanoparticles, Nanotechnology, Propionibacterium acnes, Biology, Ethylene glycol, FOS: Nanotechnology, Nanotubes, Bacteria, Q, R, Nanotechnology and Imaging for Cancer Therapy and Diagnosis, Advances in Photoacoustic Imaging and Tomography, Photothermal therapy, Materials science, Anti-Bacterial Agents, Electronic, Optical and Magnetic Materials, Chemistry, FOS: Biological sciences, Physical Sciences, Medicine, Polystyrenes, Gold, Plasmonic Nanoparticles: Synthesis, Properties, and Applications, Antibacterial activity, Hydrophobic and Hydrophilic Interactions
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