PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
Copyright policy )PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, P(nominal/lambda corrected) = 5.91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS.
- Philipps-University of Marburg Germany
- Max Planck Society Germany
- University of Queensland Australia
- University of Queensland Australia
- Medical University of Vienna Austria
Canada, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Polymorphism, Single Nucleotide, 1311 Genetics, Austria, Case-Control Studies, Germany, Restless Legs Syndrome, Genetics, Humans, Genetic Predisposition to Disease, 5' Untranslated Regions, Czech Republic
Canada, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Polymorphism, Single Nucleotide, 1311 Genetics, Austria, Case-Control Studies, Germany, Restless Legs Syndrome, Genetics, Humans, Genetic Predisposition to Disease, 5' Untranslated Regions, Czech Republic
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