CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes
Copyright policy )CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes
ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. Here we report that full-length CHD8 interacts directly with beta-catenin and that CHD8 is also recruited specifically to the promoter regions of several beta-catenin-responsive genes. Our results indicate that CHD8 negatively regulates beta-catenin-targeted gene expression, since short hairpin RNA against CHD8 results in the activation of several beta-catenin target genes. This regulation is also conserved through evolution; RNA interference against kismet, the apparent Drosophila ortholog of CHD8, results in a similar activation of beta-catenin target genes. We also report the first demonstration of chromatin remodeling activity for a member of the CHD6-9 family of proteins, suggesting that CHD8 functions in transcription through the ATP-dependent modulation of chromatin structure.
- University of Michigan–Ann Arbor United States
- University of Michigan–Flint United States
Cell Nucleus, Homeodomain Proteins, Transcription, Genetic, DNA Helicases, Intracellular Signaling Peptides and Proteins, Histone-Lysine N-Methyltransferase, Models, Biological, Chromatin, DNA-Binding Proteins, Adenosine Triphosphate, Drosophila melanogaster, Gene Expression Regulation, Animals, Drosophila Proteins, Humans, RNA Interference, beta Catenin, HeLa Cells, Transcription Factors
Cell Nucleus, Homeodomain Proteins, Transcription, Genetic, DNA Helicases, Intracellular Signaling Peptides and Proteins, Histone-Lysine N-Methyltransferase, Models, Biological, Chromatin, DNA-Binding Proteins, Adenosine Triphosphate, Drosophila melanogaster, Gene Expression Regulation, Animals, Drosophila Proteins, Humans, RNA Interference, beta Catenin, HeLa Cells, Transcription Factors
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